Smoke or Cannabis-Related Businesses in Sioux Falls, South Dakota 2026
Cannabis in Sioux Falls
Sioux Falls, South Dakota's largest city, is navigating the state's developing medical cannabis program after voters approved Initiated Measure 26 in 2020. The city initially resisted cannabis retail but has since allowed medical dispensaries to operate. Sioux Falls' growing metropolitan area and Midwest hub status make it the state's most important medical cannabis market.
Sioux Falls Loud Vape & Tobacco
Smoke ShopSioux Falls, South Dakota
★★★★★The CBD Centers of Sioux Falls
CBD StoreSioux Falls, South Dakota
★★★★★Your CBD Store - Sioux Falls East, SD
CBD StoreSioux Falls, South Dakota
★★★★★Your CBD Store | SUNMED - Sioux Falls, SD
Hemp BusinessSioux Falls, South Dakota
★★★★★East River Farms Medical Dispensary
DispensariesSioux Falls, South Dakota
★★★★★Roy'zzz of Sioux Falls
DispensariesSioux Falls, South Dakota
★★★★★Roy'zzz Premium Cannabis
DispensariesSioux Falls, South Dakota
★★★★★East River Farms Medical Dispensary
DispensariesSioux Falls, South Dakota
★★★★★Genesis Farms Cannabis Dispensary
DispensariesSioux Falls, South Dakota
★★★★★VIP Smoke Shop
Smoke ShopSioux Falls, South Dakota
★★★★★Puff city smoke shop
Smoke ShopSioux Falls, South Dakota
★★★★★Herb N Legend
Hemp BusinessSioux Falls, South Dakota
★★★★★Flower Shop Dispensary
DispensariesSioux Falls, South Dakota
★★★★★CannaCare Medical Dispensary
DispensariesSioux Falls, South Dakota
★★★★★Roll N' Smoke
Smoke ShopSioux Falls, South Dakota
★★★★★Zaza smoke shop
Smoke ShopSioux Falls, South Dakota
★★★★★Smokin' Deals Tobacco Outlet
Smoke ShopSioux Falls, South Dakota
★★★★★
Genesis Farms - Sioux Falls
DispensariesSioux Falls, South Dakota
★★★★★3rd Eye Cannabinoids
Hemp BusinessSioux Falls, South Dakota
★★★★☆Green Joint Medical & Recreational Cannabis Dispensary
DispensariesSioux Falls, South Dakota
Online CBD Store
CBD StoreSioux Falls, South Dakota
Medical Dispensaries in Sioux Falls
Sioux Falls' medical dispensaries serve registered patients along 41st Street, Louise Avenue, and in commercial areas. Smoke shops carry accessories and CBD products throughout the city.
South Dakota Cannabis Rules
South Dakota permits medical marijuana for patients with qualifying conditions. Recreational cannabis was approved by voters but faced legal challenges. See our South Dakota regulations page.
Branded Products for Sioux Falls
Sioux Falls cannabis businesses can build their brand with custom products from Cannabis Promotions — branded grinders, logo accessories, and promotional items.