Top Smoke or Cannabis-Related Businesses in South Dakota 2026 Medical Only

Rapid City, South Dakota

Roll N Smoke

Brookings, South Dakota

Puff Empire Smoke Superstore

Brookings, South Dakota

Smoke Solutions

Watertown, South Dakota

Trail's Head Cannabis Co.

Cultivator

Deadwood, South Dakota

Main Street Cannabis

Consumption Lounge

Pine Ridge, South Dakota

Puffy's Dispensary

Rapid City, South Dakota

Kind Care of South Dakota

North Sioux City, South Dakota

★★★★★4.8

Flower Shop Dispensary

Sioux Falls, South Dakota

CannaCare Medical Dispensary

Sioux Falls, South Dakota

Roll N' Smoke

Sioux Falls, South Dakota

Zaza smoke shop

Sioux Falls, South Dakota

Chasing Clouds Vape and Smoke - Rapid City

Rapid City, South Dakota

Dakota Natural Growers, INC

Hemp Business

Vermillion, South Dakota

Dakota Herb LLC

Aberdeen, South Dakota

Groovy Treez Cannabis Dispensary

Yankton, South Dakota

Dakota Kind Dispensary

Hot Springs, South Dakota

Dakota Green Dispensary

Rapid City, South Dakota

Puffy's Dispensary

Rapid City, South Dakota

Genesis Farms Cannabis Dispensary

Watertown, South Dakota

Smokes 4 less

Rapid City, South Dakota

Vape Depot & Smoke Shop

Watertown, South Dakota

Smokin' Deals Tobacco Outlet

Sioux Falls, South Dakota

The Lost Lighter

Headshop

Rapid City, South Dakota

Cannabis Health

Ancillary Services

Rapid City, South Dakota

Redwater Cannabis Care - A Dakota Green Cultivators Dispensary

Belle Fourche, South Dakota

The Dispensary.

Harrisburg, South Dakota

Puffy's Dispensary

Sturgis, South Dakota

Groovy Treez Cannabis Dispensary

Yankton, South Dakota

Dakota Herb - Vermillion

Vermillion, South Dakota

★★★★★4.6

Thrifty Smoke Shop

Rapid City, South Dakota

★★★★★4.5(Google)

Native Nations Cannabis Dispensary

Flandreau, South Dakota

★★★★★4.5(Google)

Yellowstone Cannabis Care - A Dakota Green Cultivators Dispensary

Fort Pierre, South Dakota

★★★★★4.5(Google)

Genesis Farms - Sioux Falls

Sioux Falls, South Dakota

★★★★★4.5

Black Hills CBD

CBD Store

Rapid City, South Dakota

America's Smoke - Brookings SD

Brookings, South Dakota

Smoke Solutions Superstore - North

Headshop

Rapid City, South Dakota

3rd Eye Cannabinoids

Hemp Business

Sioux Falls, South Dakota

Solventum Brookings

Hemp Business

Brookings, South Dakota

From The Hills Cannabis Dispensary - Lead

Lead, South Dakota

Dakota Herb - Brandon

Brandon, South Dakota

★★★★☆4.4

Smokes 4 Less Rapid City

Rapid City, South Dakota

★★★★☆4.3(Google)

605 Cannabis LLC

Ancillary Services

Worthing, South Dakota

★★★★☆4.3(Google)

Redwater Cannabis Care - A Dakota Green Cultivators Dispensary

Belle Fourche, South Dakota

★★★★☆4.3(Google)

Smokes R US

Watertown, South Dakota

★★★★☆4.0(Google)

Top Shelf ReLeaf

Platte, South Dakota

★★★★☆3.7(Google)

Willy Tanka's Cannabis Factory

Wanblee, South Dakota

★★★☆☆3.3

No Worries Dispensary

Pine Ridge, South Dakota

★★☆☆☆2.3(Google)

Green Joint Medical & Recreational Cannabis Dispensary

Sioux Falls, South Dakota

Wolf Creek Dispensary