Smoke or Cannabis-Related Businesses in Greenville, South Carolina 2026

Short answer: Greenville, South Carolina has 21 smoke or cannabis-related businesses listed for 2026. Compliance rules are set by the South Carolina regulator.

Cannabis in Greenville

Greenville, one of South Carolina's fastest-growing cities and the hub of the Upstate region, has a thriving CBD and smoke shop market despite the state's cannabis prohibition. The city's vibrant downtown, tech and manufacturing economy, and influx of transplants from legal states create growing consumer interest in cannabis reform.

Cloudz Smoke Shop — Smoke Shop in Greenville, SC

Cloudz Smoke Shop

Greenville, South Carolina

★★★★★5.0(Google)

Franny's Farmacy Greenville (CBD only)

Greenville, South Carolina

★★★★★5.0

KYLÉ Smoke Shop - Greenville — Smoke Shop in Greenville, SC

KYLÉ Smoke Shop - Greenville

Greenville, South Carolina

★★★★★4.9(Google)

Your CBD Store | SUNMED - Greenville, SC — CBD Store in Greenville, SC

Your CBD Store | SUNMED - Greenville, SC

Greenville, South Carolina

★★★★★4.9(Google)

Magic Vape and Print Shop — Hemp Business in Greenville, SC

Magic Vape and Print Shop

Greenville, South Carolina

★★★★★4.9(Google)

Sams Vape & Tobacco — Smoke Shop in Greenville, SC

Sams Vape & Tobacco

Greenville, South Carolina

★★★★★4.9(Google)

Holy Smoke — Hemp Business in Greenville, SC

Holy Smoke

Greenville, South Carolina

★★★★★4.9(Google)

I Heart CBD Greenville — Dispensaries in Greenville, SC

I Heart CBD Greenville

Greenville, South Carolina

★★★★★4.8(Google)

Downtown Tobacco & Vape — Smoke Shop in Greenville, SC

Downtown Tobacco & Vape

Greenville, South Carolina

★★★★★4.8(Google)

CBD Farmacy - CBD, Delta 8, Delta 9 — CBD Store in Greenville, SC

CBD Farmacy - CBD, Delta 8, Delta 9

Greenville, South Carolina

★★★★★4.8(Google)

Dragon puff tobacco &vape — Smoke Shop in Greenville, SC

Dragon puff tobacco &vape

Greenville, South Carolina

★★★★★4.8(Google)

Viva Smoke & Vape ~VAPE Gallery ~ — Hemp Business in Greenville, SC

Viva Smoke & Vape ~VAPE Gallery ~

Greenville, South Carolina

★★★★★4.8(Google)

HAYWOOD TOBACCO & VAPE — Smoke Shop in Greenville, SC

HAYWOOD TOBACCO & VAPE

Greenville, South Carolina

★★★★★4.8(Google)

VaporWize — Hemp Business in Greenville, SC

VaporWize

Greenville, South Carolina

★★★★★4.8(Google)

Smokeville Smoke Shop — Smoke Shop in Greenville, SC

Smokeville Smoke Shop

Greenville, South Carolina

★★★★★4.7(Google)

Smoke 'n Brew — Smoke Shop in Greenville, SC

Smoke 'n Brew

Greenville, South Carolina

★★★★★4.7(Google)

Greenville Tobacco & Vape — Smoke Shop in Greenville, SC

Greenville Tobacco & Vape

Greenville, South Carolina

★★★★★4.7(Google)

Smoke N Brew 2 — Smoke Shop in Greenville, SC

Smoke N Brew 2

Greenville, South Carolina

★★★★★4.6(Google)

Garner's Natural Life - Woodruff — Hemp Business in Greenville, SC

Garner's Natural Life - Woodruff

Greenville, South Carolina

★★★★★4.6(Google)

Upstate 2 Tobacco & Vape — Smoke Shop in Greenville, SC

Upstate 2 Tobacco & Vape

Greenville, South Carolina

★★★★★4.6(Google)

Get Weird Vape Smoke Shop — Smoke Shop in Greenville, SC

Get Weird Vape Smoke Shop

Greenville, South Carolina

★★★★☆4.4(Google)

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CBD and Smoke Shops in Greenville

Greenville's smoke shops and CBD retailers are found along Woodruff Road, Haywood Road, and in the downtown area near Falls Park. These shops carry hemp products, accessories, and CBD wellness items.

Greenville Cannabis Rules

South Carolina: no legal cannabis program. Marijuana is illegal. Hemp CBD available. Visit our South Carolina regulations page.

Branded Products for Greenville

Greenville smoke shops can differentiate with branded merchandise from Cannabis Promotions — custom accessories and logo items.

Listings & accuracy: Business listings are aggregated from public sources and user submissions and may be inaccurate, incomplete, or out of date. Inclusion is not an endorsement, and Cannabis Promotions does not independently verify the licensing or legal status of listed businesses — always confirm directly with the business and the relevant state or provincial regulator. Reviews reflect the views of their authors, not Cannabis Promotions.

Not professional advice: Content is provided for general informational purposes only and does not constitute legal, financial, tax, or other professional advice.

Age & products: You must be 21 or older to use this site. Cannabis Promotions provides custom branding, merchandise, and packaging products only — we do not sell, distribute, or facilitate the sale of cannabis, THC, or any controlled substance.