Root 66 Dispensary – Dogtown, MO

Root 66 Dispensary in Dogtown, MO, serves as a premier destination for both recreational and medical cannabis consumers in Saint Louis. Located at 6660 Manchester Ave, this dispensary is situated in a vibrant district known for its rich history and local culture. As one of the first medical marijuana dispensaries to open within the City of St. Louis, the facility prides itself on providing a welcoming environment for adults aged 21 and older, as well as medical patients who hold a valid card. With a focus on customer experience, the knowledgeable team at the Dogtown location is dedicated to helping visitors navigate their wide selection of high-quality products.

The dispensary offers an extensive inventory, including cannabis flower, vapes, concentrates, edibles, beverages, and more. To ensure convenience for the local community, the shop provides an efficient "order ahead" service for both recreational and medical shoppers, alongside a dedicated drive-thru for quick, accessible pickups. Whether you are a long-time enthusiast or a first-time visitor, the team is committed to delivering a professional and helpful experience. Open daily from 8 AM to midnight—with extended drive-thru hours on select evenings—Root 66 remains a cornerstone of the St. Louis cannabis scene. Cannabis businesses looking for custom branded accessories (lighters, grinders, rolling papers, trays) can get wholesale pricing at Cannabis Promotions.